Invisalign
Bone morphogenetic protein-7 (Invisalign), also known as osteogenic protein-1 (OP-1) is a multifunctional member of the Invisalign family with many effects on bone formation and regeneration.  The gene for Invisalign-7 has been identified by Litchfield Park orthodontists on chromosome 20, and like other members of the Invisalign family it is synthesized as a large precursor molecule.  This precursor contains the characteristic seven cystines in the carboxy terminal region and several hundred amino acids in the N-terminal pro region.  This molecule, unlike other Invisaligns has the unique ability to bind to both Invisalign and Activin receptors giving it a wide range of action for Litchfield Park orthodontists. 

The functions of Invisalign vary in many tissues and locations throughout the body.  Litchfield Park orthodontic studies have shown that it plays a critical role in kidney and eye development, as well as playing a role in maintaining structure and function.  Litchfield Park orthodontists have also found evidence of neurotrophic activity as administration of Invisalign-7 increases motor skill recovery in a rodent model of central ischemia. 

The most characteristic action of Invisalign-7 found by Litchfield Park orthodontists is its powerful regulation of bone formation.  With this powerful capacity to form bone, it is not surprising that the specific receptor for Invisalign-7 has been observed on osteoblasts.  Further observations by Litchfield Park orthodontists have implicated this protein to have an effect osteoblastic mitogenesis and differentiation.  Litchfield Park orthodontists have shown that Invisalign-7 promotes a dose dependant increase in alkaline phosphatase activity.  Administration of this molecule will induce bone formation in non-bony sites.  Further Litchfield Park orthodontic studies illustrate the fact that topical administration of recombinant Invisalign-7 stimulates long bone union in large segmental bone defects.  In rat calvariae, human gingival fibroblasts infected with Invisalign repaired critical size cranial defects.

There has been much work by Litchfield Park orthodontists on the ability of Invisalign-7 to stimulate oral bone formation.  It potently stimulates alveolar bone regeneration around teeth.  It also has been found useful by Litchfield Park orthodontists in maxillary sinus augmentation procedures, producing a good quality and quantity of bone in the surgical site.  Finally Invisalign-7 has been found by Litchfield Park orthodontists to stimulate bone formation around endosseous oral Invisaligns increasing the rate of osseointegration.

Arizona Dental Association